![]() This site was established in 2006 to serve as a source of information on LipidRescue™ methodology and related issues. The intent was to provide a venue for the robust exchange of ideas on topics including the mechanisms, epidemiology, diagnosis, presentation, prevention and treatment of life-threatening local anesthetic overdose and other types of severe cardiac and CNS toxicity.Ĭontent includes the aforementioned aspects of local anesthetic toxicity plus links to related educational sites, typical experiments from my (the Weinberg) lab that are posted on YouTube for you to review, lipidrescue guidelines in several languages that you can download for free (find in the Navigator under 'Instructions') and use in your institution (e.g., laminate and post in the block room), some suggestions about how to institute a program, and a place to post interesting and/or educational cases - this is how we will all learn more about the setting, context, causes, clinical spectrum and treatment of all causes of toxicity. Initial support for this view was provided by a most remarkable case report where lipid emulsion infusion apparently saved a patient from overwhelming bupropion overdose. Since then, evidence from both laboratory models and case reports, indicates that LipidRescue™ can effectively in treat a wide variety of non-local anesthetic overdoses, including reversal of both cardiovascular and central nervous system (CNS) signs and symptoms of toxicity. More recently, LipidRescue™ has been shown in peer-reviewed medical literature and elsewhere to be an effective antidote for poisoning or overdose caused by a wide array of other (non-local anesthetic) lipophilic agents. LipidRescue TM was originally developed to treat local anesthetic toxicity, a potentially fatal complication of regional anesthesia that can also occur in other situations where patients receive local anesthetic injections. All rights reserved.LipidRescue™ resuscitation refers to the intravascular infusion of 20% lipid emulsion to treat severe, systemic drug toxicity or poisoning. Intravenous lipid emulsion therapy stands as a salvage treatment for CCB intoxications with cardiovascular failure unresponsive to standard supportive treatments.Ĭopyright © 2022 Wolters Kluwer Health, Inc. All patients were discharged with complete recovery at the sixth day of pediatric intensive care unit admission. Hemodynamic instability improved immediately after intravenous lipid emulsion treatment. ![]() Intravenous lipid emulsion (dose: 20% lipid emulsion given as a 1.5-mL/kg bolus followed by 0.25-0.5 mL/kg/min for 30-60 minutes) treatment was given to all patients unresponsive to initial treatments. All patients were hospitalized in pediatric intensive care unit because of hypotension, and they were initially treated with fluid boluses, glucagon, calcium infusion, vasopressors, inotropes and insulin. ![]() ![]() Hereby we report 4 adolescent patients who arrived to the pediatric emergency department after intentional CCB ingestions. This study aimed to describe the use and efficacy of intravenous lipid emulsion treatment in our CCB overdose patients in tandem with a comprehensive literature investigation. Calcium-channel blocker (CCBs) intoxication remains the most lethal among all other drug overdoses (Arroyo and Kao. ![]()
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